Medical Evidence Matters with Liz Tucker

How To Keep Your Brain Healthy Into Old Age

Neuroscientist Dr Sabina Brennan argues that while we may be increasingly aware of the importance of physical health, we neglect the value of brain health.
By giving our brains the right stimulation, she believes, not only can we increase our odds of either avoiding or delaying serious diseases such as Alzheimer’s, we may actually be able to build in resilience and slow down the ageing of our brains.
Sabina discusses the research that shows how essential it is that at every stage of our lives, our brains receive the right input at the right time. And she argues that we completely fail to understand the teenage brain. Our brains are not fully formed until we are around 24, and due to this, in our adolescence we are more like to indulge in risk taking, and are also at high risk of addictive behaviour. Yet she believes that neither society nor the way parent our teenagers really takes this into account.
Sabina was responsible for running Trinity College, Dublin’s Brain Fit, a study of brain health, lifestyle, genetics and dementia.  And she has published a number of books about brain health including 100 Days to a Younger Brain and Brain Fog. Sabina also has a website Superbrain with advice on how to enhance brain health and has a particular interest in promoting the public understanding of science. 
https://superbrain.ie/
If you would like to support this podcast you can do so via Patreon at or via PayPal.
The host of the podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on Twitter at https://twitter.com/lizctucker and read her Substack newsletter about the podcast at https://liztucker.substack.com
Medical Matters with Liz Tucker has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/

Anorexia: A Patient’s Story

As a teenager, journalist Hadley Freeman spent over two and half years in hospital being treated for anorexia. In this interview, she gives a brutally honest account of her experience and describes how she was finally able to recover from what is one of the most puzzling psychiatric diseases.
She has just published a book about her illness called: Good Girls: A Story and Study of Anorexia, and during her research for it, also spoke to many experts and patients. Anorexia remains an incredibly difficult disease to treat with the highest mortality rate of any psychiatric condition - of around 1/3.
Perhaps most revealing of all, Hadley discusses the thought processes that an anorexic patient can go through which to an outsider or worried parent can seem so illogical. And she explains the advice she would give to a parent today, who has a child with anorexia.
Hadley Freeman is a staff writer at The Sunday Times. Prior to that she worked at The Guardian and her articles have appeared in many other publications too.
Good Girls: A Story and Study of Anorexia by Hadley Freeman is published by 4th Estate
For anyone with an eating disorder or supporting someone with an eating disorder, the charity Beat Eating Disorders offers help and support:
https://www.beateatingdisorders.org.uk/get-information-and-support/get-help-for-myself/i-need-support-now/helplines/
If you would like to support this podcast you can do so via Patreon at or via PayPal.
The host of the podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on Twitter at https://twitter.com/lizctucker and read her Substack newsletter about the podcast at https://liztucker.substack.com
Medical Matters with Liz Tucker has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/

Pain: Why We Need to Revolutionise Our Thinking

Dr Deepak Ravindran, a NHS consultant in pain medicine, reveals how we need to completely rethink our views about pain.
Pain, particularly long term intractable chronic pain, can be one of the most difficult medical conditions to live with, making normal work or life almost impossible. Globally around 20% of people suffer from the condition. And getting the help they need can be incredibly difficult.
Ravindran explains how many of us totally misunderstand pain. The problem can be someone with chronic pain can have a battery of tests that all come back clear, which may lead some medical professionals to suggest that there is not actually anything wrong with these patients. But that is not the case.
For the first time in 2022, the World Health Organisation updated the International Classification of Diseases to include chronic pain as a separate medical condition.
And as Ravindran reveals, the biological mechanism of chronic pain, which can lead to an over-sensitised immune and nervous system is not the same as acute pain. That means a very different treatment is required, using not just drugs, but taking a whole body approach which includes diet, exercise, sleep and cognitive techniques. It’s a technique that has had life-changing consequences for patients, who have often suffered for years with crippling chronic pain.
In the podcast, Ravindran discusses the importance of being cautious about every drug that is given for pain management and recommends the following website:
https://thennt.com/
The Pain-Free Mindset: 7 Steps to Taking Control and Overcoming Chronic Pain by Dr Deepak Ravindran is published by Vermilion
If you would like to support this podcast you can do so via Patreon at or via PayPal.
The host of the podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on Twitter at https://twitter.com/lizctucker and read her Substack newsletter about the podcast at https://liztucker.substack.com
Medical Matters with Liz Tucker has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/

Why Having a Healthy Microbiome Is Critically Important

Colorectal surgeon Mr James Kinross reveals the remarkable impact that our microbiomes have on every aspect of health from the moment we are born. He argues that the biome may hold the key to understanding diseases as varied as cancer, bowel and auto-immune conditions.
And that the rise of these conditions may be at least partially due to the disruption that’s been caused to our biomes, by the food we eat, antibiotics and the environment around us.
In his new book: Dark Matter: The New Science of the Microbiome, James even suggests that the way a man and woman’s biome interacts may have an  impact their ability to reproduce.
James Kinross is a senior lecturer in colorectal surgery and a  surgeon at Imperial College London. He leads a research team exploring how the microbiome may drive cancer and other diseases of the gut.
Dark Matter: The New Science of the Microbiome by Dr James Kinross is published by Penguin Random House.
If you would like to support this podcast you can do so via Patreon at or via PayPal.
The host of the podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on Twitter at https://twitter.com/lizctucker and read her Substack newsletter about the podcast at https://liztucker.substack.com
Medical Matters with Liz Tucker has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/

Using Low Carb Diets To Treat Epilepsy And Other Neurological Diseases

Dr Tanya JW McDonald discusses the use of low carb (otherwise known as ketogenic) diets for patients with epilepsy, Alzheimer’s Disease, malignant glioma and other neurological conditions.
Remarkably, low carb diets have been used successful to treat  patients with epilepsy for 100 years, but fell out of favour when drugs were developed. However, in recent years there has been a resurgence in the use of these diets, and studies suggest that around 50% of pediatric and 40% of adult patients whose epilepsy is resistant to drug therapy can be helped with a low carb diet.
And in malignant glioma, a form of brain cancer, some research now suggests that tumour cells prefer glucose. So following a low carb diet cuts sugar, removing this potential cancer cell fuel source.
So is it possible that food can access neurological pathways that drugs can’t? And what implications does this have for the treatment of other neurological diseases?
Dr Tanya J. W. McDonald is a neurologist based at Johns Hopkins Hospital in the US. She focuses on the diagnosis and treatment of epilepsy and seizures. Her particular interests include dietary therapies for adults with epilepsy, evaluations for seizure surgery and epilepsy in women.
If you would like to support this podcast you can do so via Patreon at or via PayPal.
The host of the podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on Twitter at https://twitter.com/lizctucker and read her Substack newsletter about the podcast at https://liztucker.substack.com
Medical Matters with Liz Tucker has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/

Your 24 Hour Body Clock: How It Controls Everything from Sleep To When You Should Take Medication

Russell Foster, Professor of Circadian Neuroscience at Oxford University,  reveals the key role our body clock plays not just in controlling how and when we sleep, but in every aspect of our biology and health.
He discusses his tips for getting a good night's sleep and what do when you just can’t drop off. And explores the huge toll that shift work takes on both our physical and mental health, so much so that the World Health Organization has described the link between shift work and cancer as probably carcinogenic.
Russell goes on to explain why modern medicine needs to pay far more attention to the impact that our body clock has on the time of day we should take certain drugs.
Remarkably, one study revealed that if you take an aspirin for stroke prevention,  it can be 50% more effective depending on the time of day you take it.  And another trial for the treatment of ovarian cancer discovered there was a fourfold difference in a successful outcome depending on when in the 24 hour cycle the chemotherapy was taken.
 
Russell Foster is Professor of Circadian Neuroscience, Director of the Sir Jules Thorne Sleep and Circadian Neuroscience Institute, and  Head of the Nuffield Laboratory of Ophthalmology at Oxford University. He is a fellow of the Royal Society and was awarded a CBE for his services to science. And he is the author of the book Life Time: The New Science of the Body Clock, and How It Can Revolutionise Your Health.
 
If you would like to support this podcast you can do so via Patreon at or via PayPal.
The host of the podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on Twitter at https://twitter.com/lizctucker and read her Substack newsletter about the podcast at https://liztucker.substack.com
Medical Matters with Liz Tucker has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/

Can Longevity Drugs and Lifestyle Extend Our Lifespan?

The idea of staying fit, young and healthy for longer, is something many of us would love to achieve, but just how possible is it?
Dr Robert Lufkin, who has a particular research interest in the  science of longevity discusses the reality. He says the aim is not to live forever, or live longer when we are frail and ill, but to lengthen our healthy lifespan.
When we age, the odds of us getting a range of degenerative diseases or life threatening illnesses increase, so the science of anti-aging is really all about discovering why this happens and what we can do to slow or stop these pathways.
Lufkin reveals the role that he believes lifestyle, diet and exercise can play. And goes on to review drugs such as Rapamyzin that some people, including him, are now taking in the hope they can keep their bodies healthier for longer. So exactly what is the evidence that we can stave off the perils of aging?
Dr Robert Lufkin is currently Adjunct Clinical Professor of Radiology at the USC Keck School of Medicine. He is also Chief of Metabolic Imaging at a large medical network in southern California. Previously, Rob has been president of the society of magnetic resonance imaging, president of the American society of head and neck radiology. In addition to being a practicing physician, he is author of over 200 peer reviewed scientific papers and 14 books.
Link to the web page of Dr Lufkin's website with research paper references, some of which are discussed in this podcast: https://www.robertlufkinmd.com/academic-papers/
If you would like to support this podcast you can do so via Patreon at or via PayPal.
The host of the podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on X and read further information about the podcast on her Substack newsletter.
Medical Matters with Liz Tucker has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/

Should You Take A Statin?

Dr John Abramson, who has published several peer reviewed papers examining the data behind statins, discusses the facts you need to know before deciding with your doctor whether to take one of these drugs or not.
Statins are drugs that lower cholesterol levels and the numbers of people recommended to take them continues to increase. Just this year, the UK’s National Institute of Clinical Excellence, NICE, has extended its recommendations to suggest that those with a less than 10% 10 year risk of heart disease consider taking one.
Yet interestingly, the vast majority of the clinical trial data had been collected ten years ago. So the podcast explores the basis on which these new recommendations are being made.
Dr Abramson discusses the risks and benefits of statins, which will vary depending on if you are male or female, and if you are at high or low risk from heart disease.  
And just to note, in this podcast we talk about US and UK recommendations, but both are based on the same clinical trial data,  which countries across the world rely on.
The key difference is the US measures cholesterol levels in milligrammes per decilitre and the UK in millimoles per litre. (To convert milligrams per decilitre to millimoles per litre divide by 18 and there are also various calculators online that can convert from one system to the other too.)
If you would like to support this podcast you can do so via Patreon at or via PayPal.
The host of the podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on X and read further information about the podcast on her Substack newsletter.
Medical Matters with Liz Tucker has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/

What You Need to Check Before Taking Any Prescription Drug

Former Canadian politician Terence Young became a safety advocate, starting the non-profit group Drug Safety Canada, following the tragic death of his 15 year old daughter Vanessa after taking the drug Propulsid. The drug was withdrawn from the North American market the day before Vanessa's funeral.
Terence argues in a new book that it’s essential that we all educate ourselves about drug safety. We can’t just leave it to doctors.  He says most of us have absolutely no idea about the true risks and benefits of the prescription drugs we take. And the only way we can find out this information is by asking the right questions.
So in this interview Terence explains the ten key points or rules we all need to know. For example, were you aware that a patient’s individual response to a drug can vary by 400 to 4,000 %? And why - unless there is a very good reason - you should try to avoid taking a drug less than seven years old?
Forbidden Knowledge: A Self-Advocate’s Guide to Managing Your Prescription by Terence Young is published by Dundurn Press
If you would like to support this podcast you can do so via Patreon at or via PayPal.
The host of the podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on X and read further information about the podcast on her Substack newsletter.
Medical Matters with Liz Tucker has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/

Sugar, Refined Carbs and Polyunsaturated Fats: The Perfect Storm?

Orthopaedic Surgeon Dr Gary Fettke frustrated by the increasing number of diabetic patients' limbs  he was having to amputate, started prescibing low sugar diets to these patients. But then found himself sanctioned by the Australian medical board for giving nutritional advice.
Fettke was told: "there's nothing associated with your medical training that makes you an expert, or authority on the field of nutrition, diabetes or cancer, you're not allowed to make any recommendations to your patients on nutrition". It would take nearly five years for the decision to be reversed.
Fettke's belief in the importance of preventative medicine began his lifelong research into the science of nutrition, dietary guidelines and exactly what makes a healthy diet.
And he has become convinced that for all of us - not just those with diabetes -  sugar, refined carbs and polyunsaturated fats come together to create a perfect storm in our bodie. That is why he believes we are seeing a higher level of metabolic illnesses such as diabetes type 2, heart disease and cancer,  than ever before.
 
Dr Gary Fettke, is an orthopaedic surgeon, based in Tasmania, Australia.  He has a particularly interest in  preventative medicine. Although his speciality is surgery, Gary believes it is much better to help patients avoid surgery if at all possible, by making dietary changes.
If you would like to support this podcast you can do so via Patreon at or via PayPal.
The host of the podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on X and read further information about the podcast on her Substack newsletter.
Medical Matters with Liz Tucker has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/